Webinar – Magnesium Glycinate: Nature’s Antidote to Constipation

Join Cyrus Kuhzarani, R.Phm., founder and formulator of Pure Lab Vitamins for an informative and practical discussion on Magnesium Glycinate – plus a question and answer period after the webinar.

DATE:  Wednesday, June 29, 2022
TIME: 6:30pm
REGISTER HERE

What you will learn:

  • What are the common causes of constipation
  • How laxatives work and why they ‘fix’ constipation
  • Which magnesium supplement corrects constipation naturally

Webinar: Protecting the Brain from Neurological & Viral Assault

Join Cyrus Kuhzarani, R.Phm., founder and formulator of Pure Lab Vitamins, for a positive discussion that will empower you with information to build the health you deserve.

Date: January 26, 2022
Time: 6:30p.m.
Register: link here

What you will learn:

  • What are the differences between neurological conditions
  • How does lifestyle impact cognitive performance
  • Which supplements support brain health
  • How has Covid-19 impacted neurological health

REGISTER HERE

Iron: An Essential Nutrient in Athletes

Having an iron deficiency, or in severe cases, anemia, can be detrimental to athletic performance and overall health. It limits the body’s capacity to carry and deliver oxygen, thus stunting potential maximal oxygen uptake (VO2 max) or work capacity. Poor iron status is also associated with higher blood lactate concentrations during exercise.

Iron is a trace mineral that is also highly significant to endurance athletes. Iron is critical to optimal athletic performance because of its role in energy metabolism, oxygen transport, and acid-base balance.

Read the full article here

Guest post – Heart Disease: Improving the Female Experience

Did you know that two thirds of clinical heart and stroke research is based on men? For too long, cardiovascular disease (CVD) has been viewed as a ‘man’s disease’, yet this condition is the number one cause of death in Canadian women.

If it sounds scary, it should. But don’t despair. After exploring women’s unique risks, I’ll explain important nutritional supplementation for maintenance of cardiovascular health.

Why Women Need to Pay Attention

There are several reasons women and men experience heart disease, diagnosis and treatment differently. Consider that women’s anatomy and physiology can make diagnosis more challenging. For example, they experience the symptoms of heart attack uniquely because of differences in heart size and artery width. With smaller hearts, females responding to stress with an increased pulse rate and less blood pumped than a man’s (larger) heart. Stressed women also don’t necessarily experience vasoconstriction of the arteries like men do, the latter who can then be diagnosed with increased blood pressure. For these reasons, stress tests have proven to be less useful for women than men.

Similarly, the angiogram–which is used to diagnose coronary artery disease (CAD) of the heart– cannot properly ‘see’ inside the small arteries, where women tend to experience coronary artery disease; meanwhile, men benefit most from the procedure because their blockages tend to occur in the larger arteries.

Misdiagnosis is Common

Coronary artery disease (CAD) is sometimes misdiagnosed in women and treated as if the problem was digestive, hormonal psychological, or respiratory instead of cardiovascular in nature. This is because symptoms can masquerade as other pathologies, given that they can range from chest pains, heart palpitations, nausea, shortness of breath, to light-headedness. This may be part of the reason fewer women are prescribed blood thinning drugs, cholesterol-lowering drugs and blood pressure drugs that are given to men after their first heart attack. As remarkably unfair as it seems, this is based on data from multiple studies that collectively looked at over 2 million American patients!

Hormonal Risk Factors Through the Life Cycle

The following hormone-related risk factors for heart disease are unique to females:

The condition endometriosis, in which the tissue normally only found inside the uterus is found growing and bleeding in other sites within the abdominal cavity, may be a risk factor for CAD. The Nurses’ Health Study II collected data on women and cardiovascular disease for 20 years. Researchers found that of 116,000 females aged 25-42 who had no previous history of heart disease or stroke incidence, those with a confirmed diagnosis of endometriosis had a 52% higher risk for heart attack, a 91% greater risk of chest pain, and 35% risk of undergoing heart surgery compared to women without endometriosis. Researchers are now trying to determine if the higher levels of systemic inflammation, cholesterol and oxidative stress experienced by endometriosis patients may be responsible for the study’s findings.

Women with Polycystic Ovarian Syndrome (PCOS), known to impact fertility, are another cohort with higher CVD risk. These women have more risk factors as this disease carries with it a very high risk of obesity and diabetes-which are CVD risk factors themselves.

Pregnancy also brings with it potential risk factors. Pre-eclampsia-characterized by hypertension during pregnancy-may also increase coronary artery disease (CAD), the leading cause of myocardial infarction (known more commonly as ‘heart attack’.) Gestational diabetes, while temporary, is also relatively common and can increase the risk of both mom and infant developing diabetes at some point in their lives, raising the risk of heart disease.

In addition, menopause brings a permanent and significant decline in estrogen production. This affects body fat distribution, increasing visceral fat (around the abdominal and chest organs), which is a risk factor for CVD. Plus, losing the protective, vasodilating benefits of estrogen means that smaller arteries may get blocked faster—accounting for the higher incidence of cardiovascular disease in post- menopausal women. Add to this the continued prescribing of hormone replacement therapy (HRT)– in which unopposed estrogen is used to offset some of the discomforts of menopause. According to the Women’s Health Initiative, which was the largest women’s health prevention study ever conducted in 2002, found that conventional combination HRT had an increased risk for CVD risk and breast cancer, among other diseases.

So, it should become obvious that women have many extra reasons to worry about developing cardiovascular disease. Aside from the commonly known sensible diet and exercise guidelines, is there anything else that can be done?

The Role of Nutritional Supplementation in CVD Prevention

There is plenty of research that has demonstrated that specific nutrients, when supplemented, provide benefits to the cardiovascular system. Just look at some of the world’s most famous peer-reviewed medical journals such as Circulation, Heart, Journal of the American College of Cardiology, European Heart Journal, and Nature Reviews Cardiology and you will find a plethora of studies using supplementary nutrients in the interest of cardiac function. Here, I’ll summarize some of the most interesting findings relevant to women and men alike.

Perhaps the most significant and exciting nutrient that supports cardiovascular health is vitamin K2. While other forms of vitamin K-2 are available in supplement form, such as MK-4, research shows that MK-7 is the most bioavailable form. It’s the MK-7 form of the vitamin that has demonstrated a significant reduction in arterial stiffness and reduced progression of the calcification that takes place during atherogenesis (the process that creates the build-up of arterial plaques). Specifically, a double- blind, randomized clinical trial in which 244 healthy postmenopausal female subjects took either 180 micrograms of MK-7 or placebo for 3 years—the longest study of its kind– demonstrated a reduction in arterial stiffness in these women. How does MK-7 work? It appears to activate matrix GLA-protein (MGP)—a protein present in blood vessel walls, which then prevents calcium from depositing in the vessels, where it doesn’t belong.

There is NO drug that can do what vitamin K2 does for us, making K2 MK-7 an obvious choice. But not all K2s are created equal. PLV Vitamin K-2 consists exclusively of micro-encapsulated MK-7-the most efficiently absorbed, stable form of vitamin K-2. It is double micro-encapsulated using a unique process that ensures compatibility with supplementary doses of minerals and a long shelf-life. This MK-7 product is dry form, soy-free, and produced from rose and geranium oils.

Other nutrients that can make a positive difference to cardiovascular health include:

Magnesium relaxes the blood vessels, lowering blood pressure-important because hypertension is both a risk factor for, and a complication of CAD. Low magnesium status is also associated with diabetes and Metabolic Syndrome (high cholesterol, hypertension and hyperglycemia concurrently), which are risk factors for CAD. Plus, consuming insufficient magnesium can exacerbate irregular heart beat (arrhythmia), heart muscle diseases (cardiomyopathies) and heart attack (myocardial infarction).

Coenzyme Q10 is a valuable antioxidant, protecting lipid membranes from oxidation—the latter which is a key factor in the atherosclerotic process. CoQ10 is a co-factor in the generation of cellular ATP, or energy, used in great quantity by the heart muscle. The randomized, controlled multicenter trial Q- SYMBIO concluded that long term treatment of patients with chronic heart failure was a safe, effective adjunct treatment that improved symptoms and reduced major adverse cardiovascular events. It’s important to realize that while the nutrient can be produced by the human body, ironically, statin drug use for cholesterol control interferes with its production, necessitating supplementation.

Taurine is an amino acid found in the highest concentration in the heart. It too possesses antioxidant benefits, but also has demonstrated anti-inflammatory effects in cases of acute coronary artery disease, producing anti-atherosclerotic activity in animal models. Additionally, taurine helps maintain magnesium and potassium with the heart’s cells–critical for electrical stability, strength and regularity of the heart’s contractions used to pump blood.

Synergy is everything, and nutrients need teammates to work effectively. PLV Magnesium Glycinate+Taurine+CoQ10 is a formula that combines these three synergistic nutrients that support cardiovascular function. Taking four capsules daily is considered a safe and side-effect-free way to protect the heart.

Better Representation is Happening Now

Thankfully, the research tide is turning, with more and more studies shifting to even out the gender disparities in cardiovascular research. Utilizing nutritional supplementation to support heart health should not be a missed opportunity, especially given the sobering statistics that have shown higher rates of deadly, acute coronary events in Canadian women. Cardiac patients can take action now by talking to their doctor or pharmacist about this exciting research. But don’t wait until you’re a cardiac patient—or a statistic-to do something proactive for your health. Whether you’re female or male, the benefits of nutrient supplementation here are clear.

References/Further reading

  1. Cleveland Clinic. Women or Men-Who Has a Higher Risk of Heart Attack? February 21, 2020.
  2. DiNicolantonio JJ, Liu J, O’Keefe JH. Magnesium for the prevention and treatment of cardiovascular disease. Open Heart. 2018;5(2):e000775. Published 2018 Jul 1.
  3. Harvard Health Publishing, Harvard Medical School. Endometriosis linked to increased risk of heart disease. June 2016.
  4. Harvard Health Publishing, Harvard Medical School. Gender differences in cardiovascular disease: Women are less likely to be prescribed certain heart medications. July 16 2020.
  5. Heart and Stroke.ca “Women and Heart Disease”. Accessed February 2, 2021.
  6. Knapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer C. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. Thromb Haemost. 2015 May;113(5):1135-44.
  7. Maas AH, Appelman YE. Gender differences in coronary heart disease. Neth Heart J. 2010;18(12):598-602.
  8. Melloni C, et al. Representation of women in randomized clinical trials of cardiovascular disease prevention. Circ Cardiovasc Qual Outcomes. 2010 Mar;3(2):135-42.
  9. McCarty MF. A taurine-supplemented vegan diet may blunt the contribution of neutrophil activation to acute coronary events. Med Hypotheses. 2004;63(3):419-25.
  10. Mortensen SA, Rosenfeldt F, Kumar A, Dolliner P, Filipiak KJ, Pella D, Alehagen U, Steurer G, Littarru GP; Q-SYMBIO Study Investigators. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. JACC Heart Fail. 2014 Dec;2(6):641-9.
  11. Mosca L, Barrett-Connor E, Wenger NK. Sex/gender differences in cardiovascular disease prevention: what a difference a decade makes. Circulation. 2011;124(19):2145-2154.
  12. Mu F, Rich-Edwards J, Rimm EB, Spiegelman D, Missmer SA. Endometriosis and Risk of Coronary Heart Disease. Circ Cardiovasc Qual Outcomes. 2016;9(3):257-264.
  13. Office of Women’s Health, U.S. Department of Health and Human Services. “Largest Women’s Health Prevention Study Ever-Women’s Health Initiative.” Accessed Feb. 2, 2021.
  14. UT Southwestern Medical Center. Do you have endometriosis? Why your heart may be at risk. October 31, 2016
  15. van Ballegooijen AJ, Beulens JW. The Role of Vitamin K Status in Cardiovascular Health: Evidence from Observational and Clinical Studies. Curr Nutr Rep. 2017;6(3):197-205.

Nutritional Deficiencies in Crohn’s Disease & Colitis

By Andrea Bartels CNP NNCP RNT

Registered Nutritional Therapist


Iron deficiency

To diagnose Crohn’s, a variety of tests are usually required and include blood testing, medical imagery and a colonoscopy to confirm the presence of the disease. Checking blood levels of ferritin and hemoglobin will usually identify the most common nutrient deficiency in Crohn’s and colitis patients: iron-deficiency anemia. In fact, 60 to 80 percent of IBD patients typically have iron deficiency. (9) This is for two reasons. First, the substantial blood loss that occurs during flare- ups of ulceration leads to not only a loss of iron, but loss of red blood cells themselves. Oxygen-carrying hemoglobin becomes deficient, leading to the classic picture of iron-deficiency anemia, with fatigue, weakness, and pallor. But the second reason for iron deficiency in these patients has to do with absorptive capacity. Iron absorption becomes difficult as the small intestinal surface’s brush border of villi—used to transport nutrients from the digestive tract into the bloodstream—becomes compromised. This occurs from the damage that chronic inflammation causes, and by surgical removal of chronically ulcerated small intestine. Iron repletion is not a task easily accomplished through diet alone. The mineral is famously difficult to absorb, especially in its inorganic format. Supplementary iron has a reputation for having side effects like nausea and constipation, but this is most commonly experienced with iron sulfate and ferrous fumarate, which have poor absorbability. (4, 9) However, not all iron supplements produce these unpleasant side-effects. Compounding iron with amino acids, for example, can reduce the risk of side effects dramatically, simply because the iron is absorbed before it has any chance to cause discomfort. For an already sensitive digestive tract, it makes sense to recommend organic iron compounds that have greater absorbability.

Vitamin B-12

As with iron, deficiency of vitamin B12 is not usually about inadequate intake, but rather, blood loss and limited absorption by the Crohn’s patient. (1) Since vitamin B-12 is absorbed in the lowest portion (the ileum) of the small intestine, IBD patients who have had surgical removal of part of/all of their ileum would be at highest risk of deficiency. That’s why taking B-12 under the tongue (sublingually) is the sure-fire way to get it into the bloodstream. Methylcobalamin is the biologically active form of B-12 that, when used sublingually, is a more direct and efficient way (outside of injection) to ensure blood levels of B12 are there to support the nervous system and healthy hemoglobin synthesis in these patients.

Vitamin D

Being acutely ill with Crohn’s or colitis can mean little to no sun exposure, poor absorption, bowel resections, and inadequate dietary intake, so deficiencies in vitamin D are common. In fact, while Crohn’s is less common in children than in adults, in kids with inflammatory bowel disease vitamin D and iron are the two most prevalent nutritional deficiencies found. (3, 9) Vitamin D appears to influence the amount of inflammation generated by the immune system as it is an immune-modulator. Perhaps this is why researchers have found that high vitamin D levels appear to be a protective factor in Crohn’s disease, and potentially in colitis as well. In one study, vitamin D was demonstrated to be necessary for the regeneration of the epithelial cells within the small intestine of experimental mice, suggesting that further studies could identify if the same benefit could influence the condition of human IBD sufferers. (11). No matter what age, for individuals with excessive inflammation vitamin D supplementation presents an opportunity to promote normal functioning of the immune system.

Folate

Folate status is another nutrient that has a significant association with Crohn’s and colitis when compared to those without IBD (7). Not only that, but the implications of low folate status include high blood levels of homocysteine, which is a risk factor for cardiovascular events such as thrombosis. (9,12) Since there are genetic variations in folate metabolism that could be at the foundation of IBD development, a biologically active form of folate– such as 5-methyltetrahydrofolate-may be indicated.

Vitamin K

In a Japanese study, deficiencies in vitamin K and vitamin D were very common among IBD patients, despite the fact that dietary consumption was higher in this group than Japanese guidelines for recommended daily intake. (5) Since vitamin K is manufactured by intestinal bacteria, and IBD flare ups are characterized by frequent stool evacuation, it stands to reason that flares leading to substantial loss of microbiota would impact vitamin K levels. In a study of children with Crohn’s and children with UC, 54 percent of those with CD and 43.7 percent of those with UC were deficient in vitamin K. (6) Not only is vitamin K required for healthy calcification of bones, but it also serves as a coagulant of the blood. Realizing that blood loss by IBD sufferers leads to the complication of anemia, supplementary vitamin K could be of benefit under medical supervision.

Nutritional Supplementation is Key

Currently, gastroenterologists prescribe a variety of anti-inflammatory drugs to manage the symptoms of Crohn’s in their patients. However many individuals find that pharmaceuticals alone are not effective in managing their symptoms. While there isn’t a specific dietary protocol recommended by gastroenterologists, patients are often advised to follow a low-residue diet. This is a diet low in fiber, to avoid further injury to the intestinal tract while it’s ulcerated. While it makes sense to minimize the intake of scratchy roughage fibres during active (bleeding) Crohn’s, using a low-fiber diet as long term management can limit a patient’s intake of essential nutrients found only in fruits and vegetables, such as folate, vitamin C and beta-carotene. Fruits and vegetables that are cooked and puréed, or juiced may be better tolerated. However, it can still be challenging to replenish depleted nutrient levels through diet alone due to the compromised absorption and blood loss experienced by Crohn’s patients. Therefore, appropriate dosing of specific nutritional supplementation could make a significant difference to nutritional status.

Prognosis

Certain circumstances once meant that Crohn’s flare-ups could be fatal due to the complications of excessive blood loss, blockages and multiple resection surgeries but today, prognosis is far better, with Crohn’s patients living higher quality lives, and living longer than ever before. Clearly, there are good reasons to employ supplementary nutrients in Crohn’s and colitis patients. With careful attention to nutritional status, stress management and regular monitoring by health care practitioners who are well-versed in the challenges of Crohn’s and colitis, the well-being of these patients stands a very good chance of improvement.

References

  1. Battat R., Kopylov U., Szilagyi A., Saxena A., Rosenblatt D.S., Warner M., Bessissow T., Seidman E., Bitton A. Vitamin B12 deficiency in inflammatory bowel disease: Prevalence, risk factors, evaluation, and management. Inflamm. Bowel Dis. 2014;20:1120-1128.
  2. Domislović V, Vranešić Bender D, Barišić A, Brinar M, Ljubas Kelečić D, Rotim C, Novosel M, Matašin M, Krznarić Ž. HIGH PREVALENCE OF UNTREATED AND UNDERTREATED VITAMIN D DEFICIENCY AND INSUFFICIENCY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE. Acta Clin Croat. 2020 Mar;59(1):109-118.
  3. Fritz J, Walia C, Elkadri A, Pipkorn R, Dunn RK, Sieracki R, Goday PS, Cabrera JM. A Systematic Review of Micronutrient Deficiencies in Pediatric Inflammatory Bowel Disease. Inflamm Bowel Dis. 2019 Feb 21;25(3):445-459.
  4. Kaitha S, Bashir M, Ali T. Iron deficiency anemia in inflammatory bowel disease. World J Gastrointest Pathophysiol. 2015;6(3):62-72.
  5. Kuwabara A, Tanaka K, Tsugawa N, Nakase H, Tsuji H, Shide K, Kamao M, Chiba T, Inagaki N, Okano T, Kido S. High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease. Osteoporos Int. 2009 Jun;20(6):935-42.
  6. Nowak JK, Grzybowska-Chlebowczyk U, Landowski P, et al. Prevalence and correlates of vitamin K deficiency in children with inflammatory bowel disease. Sci Rep. 2014;4:4768.
  7. Pan Y, Liu Y, Guo H, et al. Associations between Folate and Vitamin B12 Levels and Inflammatory Bowel Disease: A Meta-Analysis. Nutrients. 2017;9(4):382.
  8. Schäffler H, Schmidt M, Huth A, Reiner J, Glass ä, Lamprecht G. Clinical factors are associated with vitamin D levels in IBD patients: A retrospective analysis. J Dig Dis. 2018 Jan;19(1):24-32.
  9. Stein J, Dignass AU. Management of iron deficiency anemia in inflammatory bowel disease – a practical approach. Ann Gastroenterol. 2013;26(2):104-113.
  10. Yakut M, Ustün Y, Kabacam G, Soykan I. Serum vitamin B12 and folate status in patients with inflammatory bowel diseases. Eur J Intern Med. 2010 Aug;21(4):320-3.
  11. Zhao H, Zhang H, Wu H, Li H, Liu L, Guo J, Li C, Shih DQ, Zhang X. Protective role of 1,25(OH)2 vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice. BMC Gastroenterol. 2012 May 30; 12():57.
  12. Zezos P, Papaioannou G, Nikolaidis N, Vasiliadis T, Giouleme O, Evgenidis N. Hyperhomocysteinemia in ulcerative colitis is related to folate levels. World J Gastroenterol. 2005;11(38):6038-6042.

Vitamin C: A Game-Changer in the Recovery from Infection

By Andrea Bartels CNP NNCP RNT
Registered Nutritional Therapist

27 Jul 2020

There are several ways that vitamin C fights infectious agents. It enhances the production and proliferation of both B and T lymphocytes, immune cells involved in response to infection. It improves the mobility of phagocytes-the cells that ‘eat’ pathogens and infected tissue. Additionally, vitamin C is involved in antibody production against pathogens, so that we have immunity to them the next time they come around. Further, as an antioxidant, this vitamin also regenerates other antioxidants like glutathione and vitamin E-resulting in even greater protection against the oxidative stress caused by the inflammatory response to infection. Finally, in high doses, ascorbic acid has also been shown to be toxic to certain pathogens and abnormal cells. Put all these talents together, and you can see how valuable vitamin C is to our immune systems.

In a clinical trial of 715 students aged 18 to 32 years of age, 252 students took 1000 milligrams of vitamin C for the first 6 hours once cold and flu symptoms set in, then 3 times daily after that. Compared to the control group-who took pain relievers and decongestants instead-the Vitamin C -treated students experienced an 85 percent reduction in symptoms.

In a randomized controlled double-blind trial, 57 elderly patients that were admitted to hospital with acute bronchitis or bronchopneumonia were given either 200 milligrams of ascorbic acid (vitamin C) or placebo daily. The results: those who actually took the vitamin C had significantly better symptom improvement than those taking placebo.

In a meta-analysis of 18 controlled trials involving a total of 2004 patients, the length of stay in the ICU was reduced in those given supplementary vitamin C due to improvements in their status). What’s more, those patients who were put on ventilators for over 24 hours and were given C simultaneously had an 18.2 percent reduction in duration of ventilation (with improvements in their condition). Considering the poor survival rate of ventilated COVID-19-positive patients have had during the COVID-19 pandemic, hopefully this data will inspire further study within the context of the pandemic.

There are a multitude of studies that show similar results, and we can’t ignore the exciting recent observations of a highly published doctor, Paul Merik, MD. The doctor, who has treated hundreds of patients with sepsis—a condition in which bacteria has infected the bloodstream-decided that the mortality rate from the condition was unacceptably high in today’s modern world. He began treating his septic patients with an intravenously-delivered combination of the anti-inflammatory drug hydrocortisone, vitamin B-1 (thiamine) and vitamin C. After successfully curing 25 septic patients, he began sharing his successful results and protocol with other doctors. By 2017, Merik had saved the lives of all but one of the 150 septic patients he’d treated with his vitamin C – containing cocktail!

What these reports demonstrate is that vitamin C supplementation effectively enhances recovery from different kinds of viral and bacterial infections. However, waiting until one is sick to take supplementary nutrients is a missed opportunity. As they say, “an ounce of prevention is worth a pound of cure”. Taking Pure Lab Vitamin C on a daily basis helps reduce the risk of insufficiency, and supports the immune system so that it can fulfil its job description to protecting us.

Why Pure Lab Vitamin C is NOT buffered

Some individuals prone to GERD complain that vitamin C triggers the sensation of heartburn, and in these cases a less acidic version of vitamin C like calcium ascorbate is perceived to be the more comfortable choice. However, consider that GERD is associated with an acid-forming diet of processed foods and the latter is associated with calcium LOSS from the bones. Where does this calcium go? Well, consider that conditions such as heel spurs, breast cysts, arthritis, urinary blockage, atherosclerosis and other chronic inflammatory diseases all have in common the calcification of soft tissues. So, the root cause of the acidity cannot be blamed on vitamin C intake; it’s the diet that needs attention.

Sodium ascorbate is another, inexpensive way of offering a so-called buffered vitamin C product. But it’s not the ideal buffer either, because the standard North American diet already contains excessive amounts of salt. Associated with high salt intake is hypertension, and it is an all too common risk factor for heart and kidney disease.

Also, considering that larger doses of vitamin C are given orally and intravenously by some health practitioners to treat or manage certain health conditions, the cumulative intake of these mineral buffers could create serious imbalances when consumed in combination with dietary sources of calcium and sodium. That’s why PLV Vitamin C is pure, unbuffered ascorbic acid. Taken in daily divided doses, side effects of vitamin C are minimized and concern for mineral excesses or imbalances is thereby eliminated. Combined with good hygiene practices, optimizing vitamin C intake is an essential part of maintaining healthy immunity!

References

Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017;9(11):1211.

Centers for Disease Control. CDC’s Second Nutrition Report: A comprehensive biochemical assessment of the nutrition status of the U.S. population. Accessed online July 24, 2020.

Cheng RZ. Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)?. Med Drug Discov. 2020;5:100028.

Gorton HC, Jarvis K. The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections. J Manipulative Physiol Ther. 1999;22(8):530-533.

Hemilä H. Vitamin C and Infections. Nutrients. 2017;9(4):339.

Hemilä H, Chalker E. Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis. Nutrients. 2019;11(4):708.

Hunt C., Chakravorty N.K., Annan G., Habibzadeh N., Schorah C.J. The clinical effects of vitamin C supplementation in elderly hospitalised patients with acute respiratory infections. Int. J. Vitam. Nutr. Res. 1994;64:212-219.

Morrison, Jim. Could Vitamin C be the cure for deadly infections? Smithsonian Magazine, June 27, 2017. Accessed online on July 23, 2020.